The largest manufacturing site in the Pfizer network is in Kalamazoo, Michigan, with facilities spanning a total area of 90 acres. The site has a long legacy of innovation, industrial safety, and regulatory compliance, as well as an industry leading sustainability program, and produces approximately 1 million kg of API and 10 million kg of intermediates every year. This site ships products to 125 countries and currently supports sales in 113 countries. The American Chemical Society designated this facility a National Chemical Historic Landmark in recognition of its impact on steroid medicines.